Building IP: Juno Therapeutics Patent Grant Re “Antibodies And Chimeric Antigen Receptors Specific F

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2015-04-14-Frosinone-Latina 1-0 6. The chimeric antigen receptor of claim 1, wherein the antibody or antigen binding fragment thereof comprises a VH region comprising the amino acid sequence set forth in SEQ ID NO: 11, or a sequence having at least 90% amino acid sequence identity to SEQ ID NO:11, and a VL region comprising the amino acid sequence set forth in SEQ ID NO: 16, or a sequence having at least 90% amino acid sequence identity to SEQ ID NO:16. In certain embodiments, an anti-GPC3 Adnectin comprises the sequence set forth in SEQ ID NO: 3, wherein BC, DE and FG loops as represented by (X).sub.v, (X).sub.x, and (X).sub.z, respectively, have amino acid sequences at least 75%, 80%, 85%, 90%, 95%, 97%, 98%, or 99% identical to the BC, DE or FG loop sequences set forth in SEQ ID NOs: 99, 100 and 101, respectively. In some aspects, the scFv contains the VH, linker and VL as set forth in SEQ ID NO: 2, 4, 6, 8, 10, 45, 47, 49, 51, 53, 55, 57, 59, 87 89 or 207 to 225, or a sequence at least at or about 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% identical to such a sequence, but in which the VH and VL are configured in the opposite orientation, i.e. VL-VH, as compared to such sequence.

Also provided are therapeutic methods for administering the cells and compositions to subjects, e.g., patients. Huang et al., “DNA transposons for modification of human primary T lymphocytes,” Methods Mol Biol (2009) 506: 115-126. cited by applicant . Biol. (2008) 207:179-196. cited by applicant . Cell Biol. (1987) 7:2031-2034. cited by applicant . 1992) 52:127-131. cited by applicant . Natl. Acad. Sci. USA (1993) 90:8033-8037. cited by applicant . Clackson et al., “Making antibody fragments using phage display libraries,” Nature (1991) 352:624-628. cited by applicant . Dubowchik et al., “Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages,” Bioorg. Junghans et al., “Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders,” Cancer Res. Godin et al., “Microfluidics and photonics for Bio-System-on-a-Chip: a review of advancements in technology towards a microfluidic flow cytometry chip,” J Biophoton. 79 p. 1979-83. (Year: 1982). cited by examiner .

95:8910-8915 (Year: 1998). cited by examiner . It’s not just people isolating solo who are ordering up big, sex toys are a low-cost, zero-effort way to add novelty to a stale sex life. He reiterated the likelihood of Australia’s closed borders staying that way through the remainder of the year. Administration of proteins, and one or more additional therapeutic agents, whether co-administered or administered sequentially, may occur as described above for therapeutic applications. The formulations herein may also contain more than one active compounds as necessary for the particular indication being treated, preferably those with complementary activities that do not adversely affect each other. And yes, ROI (Return on Investment) shall be more than 500%. There is an EPIC holiday offer running on the site. This experience gives us a unique window into what a site has to offer. If you dont want to read the entire article, and directly want to check the MOST AWESOMEEEE Cam site, then join E.R.Cams- My Favorite and highly recommended cam site.

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